The U.S. Food and Drug Administration (FDA) approved the first generic versions of Cymbalta on December 11, 2013. The prescription medication, duloxetine delayed-release capsules, is used to treat depression other psychological conditions. Signs and symptoms of depression include depressed mood, loss of interest in once-pleasurable activities, significant appetite or weight change, insomnia or hypersomnia, restlessness/pacing, increased fatigue, impaired concentration, feelings of worthlessness or guilt, and thoughts of suicide or suicide attempts.